Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
| ▸ | S100A4 | P26447 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19283591 | 1.00 | ADORA3 (0.35) | ADORA3ARHSD11B1AKR1C3BUB1 | |
| SCHEMBL20508940 | 1.00 | ADORA3 (0.35) | ADORA3ARHSD11B1AKR1C3BUB1 | |
| SCHEMBL17398693 | 0.81 | CYP19A1 (0.35) | MAOBCYP19A1BCHEALDH1A1TOP2A | |
| SCHEMBL7572292 | 0.80 | ACHE (0.36) | MAOBCYP19A1 | |
| SCHEMBL31660734 | 0.75 | HTR2C (0.42) | ADORA3ARHSD11B1AKR1C3HTR2C | |
| SCHEMBL5108272 | 0.75 | HTR2C (0.42) | ADORA3ARHSD11B1AKR1C3HTR2C | |
| SCHEMBL19042465 | 0.73 | ALDH1A1 (0.39) | ADORA3ARHSD11B1AKR1C3HTR2C | |
| SCHEMBL7172119 | 0.72 | BUB1 (0.39) | BUB1NPC1RAB9ATOP2A | |
| SCHEMBL9053440 | 0.72 | ALDH1A1 (0.41) | KDM4EMAPTHSD17B10NPC1ALDH1A1 | |
| SCHEMBL12237554 | 0.72 | ADORA3 (0.41) | ADORA3ARHSD11B1AKR1C3HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180273573-A1 | INHIBITORS OF MENAQUINONE BIOSYNTHESIS | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2018-09-27 | — | — | US | disclosed |
| EP-3356447-A1 | INHIBITORS OF MENAQUINONE BIOSYNTHESIS | Memorial Sloan-Kettering Cancer Center (US) | 2018-08-08 | — | — | EP | disclosed |
| WO-2017059411-A9 | INHIBITORS OF MENAQUINONE BIOSYNTHESIS | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2017-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180273573-A1 | INHIBITORS OF MENAQUINONE BIOSYNTHESIS | COASY, SDHA, VKORC1 | ADORA3 4463/4885AR 2366/4885HSD11B1 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.