Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2945338 | 0.88 | ESR1 (0.50) | MAPTALDH1A1MAPK1LMNAAKR1C3 | |
| SCHEMBL19284522 | 0.87 | ALOX5 (0.50) | MAPTALDH1A1LMNAAKR1C3ALOX5 | |
| SCHEMBL30109372 | 0.87 | ALDH1A1 (0.55) | MAPTALDH1A1MAPK1LMNAALOX5 | |
| SCHEMBL1179795 | 0.79 | EGFR (0.49) | MAPTALDH1A1MAPK1LMNAALOX5 | |
| SCHEMBL15238230 | 0.79 | KDR (0.58) | ALDH1A1LMNAALOX5HPGDRAB9A | |
| SCHEMBL28457628 | 0.76 | DRD1 (0.62) | MAPTLMNAESR1ESR2 | |
| SCHEMBL14158144 | 0.76 | ESR1 (0.54) | ALDH1A1AKR1C3ESR1ESR2TP53 | |
| SCHEMBL30109408 | 0.76 | ALDH1A1 (0.54) | MAPTALDH1A1MAPK1LMNATP53 | |
| SCHEMBL29500309 | 0.76 | DRD1 (0.52) | ESR1ESR2 | |
| SCHEMBL8698788 | 0.75 | PLOD2 (0.56) | MAPTALDH1A1MAPK1LMNAALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017147047-A1 | FXR MODULATORS AND METHODS OF THEIR USE | ALIOS BIOPHARMA, INC. (US) | 2017-08-31 | — | — | WO | disclosed |