Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9482814 | 0.82 | FDPS (0.44) | FDPSSMN1; SMN2HIF1ACYP3A4CYP1A2 | |
| SCHEMBL11666362 | 0.82 | HDAC3 (0.49) | FDPSALDH1A1CA12CA1CA2 | |
| SCHEMBL10686804 | 0.79 | FDPS (0.49) | FDPSSMN1; SMN2HIF1ACYP3A4CYP1A2 | |
| SCHEMBL1147656 | 0.78 | SLC6A2 (0.52) | FDPSSMN1; SMN2HIF1ACYP3A4CYP1A2 | |
| SCHEMBL517462 | 0.78 | SMN1; SMN2 (0.57) | FDPSSMN1; SMN2HIF1ACYP3A4CYP1A2 | |
| SCHEMBL28567703 | 0.77 | FDPS (0.47) | FDPSSMN1; SMN2HIF1ACYP3A4RECQL | |
| SCHEMBL9006381 | 0.77 | POLB (0.41) | FDPSSMN1; SMN2HIF1ACYP3A4CYP1A2 | |
| SCHEMBL6722173 | 0.76 | SMN1; SMN2 (0.50) | FDPSSMN1; SMN2HIF1ACYP3A4CYP1A2 | |
| SCHEMBL8759 | 0.76 | SLC6A2 (0.56) | FDPSSMN1; SMN2HIF1ACYP3A4CYP1A2 | |
| SCHEMBL28727407 | 0.76 | SMN1; SMN2 (0.55) | FDPSSMN1; SMN2HIF1ACYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12139505-B2 | Compositions useful in therapy of autophagy-related pathologies, and methods of making and using the same | THE UNIVERSITY OF TOLEDO (US) | 2024-11-12 | — | — | US | disclosed |
| US-11084836-B2 | Compositions useful in therapy of autophagy-related pathologies, and methods of making and using the same | THE UNIVERSITY OF TOLEDO (US) | 2021-08-10 | — | — | US | disclosed |
| US-20210171553-A1 | COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2021-06-10 | — | — | US | disclosed |
| US-10882831-B2 | Compositions useful in therapy of autophagy-related pathologies, and methods of making and using the same | THE UNIVERSITY OF TOLEDO (US) | 2021-01-05 | — | — | US | disclosed |
| US-20190040091-A1 | COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2019-02-07 | — | — | US | disclosed |
| WO-2018156429-A1 | COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2018-08-30 | — | — | WO | disclosed |
| WO-2017147440-A1 | COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2017-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12139505-B2 | Compositions useful in therapy of autophagy-related pathologies, and methods of making and using the same | TFEB, BECN1, SQSTM1 | FDPS 874/4885SMN1; SMN2 420/4885HIF1A 882/4885 |
| US-20190040091-A1 | COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME | TFEB, SQSTM1, BECN1 | FDPS 946/4885SMN1; SMN2 504/4885HIF1A 1540/4885 |
| US-11084836-B2 | Compositions useful in therapy of autophagy-related pathologies, and methods of making and using the same | TFEB, SQSTM1, BECN1 | FDPS 946/4885SMN1; SMN2 504/4885HIF1A 1540/4885 |
| US-20210171553-A1 | COMPOSITIONS USEFUL IN THERAPY OF AUTOPHAGY-RELATED PATHOLOGIES, AND METHODS OF MAKING AND USING THE SAME | TFEB, BECN1, SQSTM1 | FDPS 874/4885SMN1; SMN2 420/4885HIF1A 882/4885 |
| US-10882831-B2 | Compositions useful in therapy of autophagy-related pathologies, and methods of making and using the same | TFEB, BECN1, SQSTM1 | FDPS 776/4885SMN1; SMN2 483/4885HIF1A 1322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.