Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15830503 | 0.83 | SIGMAR1 (0.58) | SIGMAR1OPRM1OPRK1HRH3HTR2A | |
| SCHEMBL17308349 | 0.82 | SIGMAR1 (0.56) | SIGMAR1OPRM1OPRK1HRH3DRD2 | |
| SCHEMBL17300861 | 0.81 | SIGMAR1 (0.55) | SIGMAR1OPRM1OPRK1HRH3HTR1A | |
| SCHEMBL21566643 | 0.78 | POLB (0.41) | L3MBTL1 | |
| SCHEMBL5149238 | 0.76 | SIGMAR1 (0.72) | SIGMAR1HRH3PSEN1PSEN2APH1B | |
| SCHEMBL14445631 | 0.75 | SIGMAR1 (0.69) | SIGMAR1HTR2ACXCR4ALDH1A1 | |
| SCHEMBL799370 | 0.74 | POLB (0.42) | L3MBTL1ALDH1A1 | |
| SCHEMBL8556599 | 0.74 | HTR7 (0.51) | SIGMAR1HRH3HTR2AHTR7 | |
| SCHEMBL6338588 | 0.73 | SIGMAR1 (0.62) | SIGMAR1L3MBTL1HTR1AHTR2AHTR7 | |
| SCHEMBL17306795 | 0.72 | HTR2A (0.41) | HTR1ADRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745291-B2 | PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof | Epizyme, Inc. (US) | 2017-08-29 | — | — | US | disclosed |