Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 10/20 | 0.51 |
| ▸ | HTR2A | P28223 | 5/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8592975 | 0.85 | NPSR1 (0.56) | HTR7HTR2AHTR2CHTR6 | |
| Hydrochloric Acid SCHEMBL8625338 | 0.84 | NPSR1 (0.55) | HTR7HTR2AHTR2CHTR6 | |
| SCHEMBL20314709 | 0.78 | HTR2A (0.47) | HTR2AHTR2CHTR6TDP1 | |
| SCHEMBL8552320 | 0.76 | HTR7 (0.70) | HTR7HTR2AHTR6SLC6A9 | |
| SCHEMBL5125937 | 0.75 | KEAP1 (0.52) | HTR2AHTR2CTDP1 | |
| SCHEMBL15830503 | 0.75 | SIGMAR1 (0.58) | HTR2AHTR2CHRH3TDP1SIGMAR1 | |
| SCHEMBL19287839 | 0.74 | SIGMAR1 (0.54) | HTR7HTR2AHRH3SIGMAR1 | |
| SCHEMBL491691 | 0.74 | SIGMAR1 (0.51) | HTR2AHTR2CHRH3MEN1KMT2A | |
| SCHEMBL8557740 | 0.74 | SLC6A9 (0.53) | HTR7HTR2AHTR2CHTR6MEN1 | |
| SCHEMBL30639804 | 0.74 | NPY5R (0.50) | HTR7HTR2AHTR2CHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883613-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-16 | — | — | EP | disclosed |
| WO-1997029097-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-14 | — | — | WO | disclosed |