SCHEMBL1929461

SCHEMBL1929461

COC(=O)c1ccc(Cl)c(C(=O)O)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.61
TP53 P04637 1/20 0.53
MAPT P10636 6/20 0.50
KDM4E B2RXH2 4/20 0.50
TDP1 Q9NUW8 3/20 0.50
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
GLA P06280 1/20 0.50
GAA P10253 1/20 0.50
HPGD P15428 1/20 0.50
CASP1 P29466 1/20 0.50
CASP7 P55210 1/20 0.50
ATM Q13315 1/20 0.50
HSD17B10 Q99714 1/20 0.50
POLB P06746 1/20 0.50
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA7 P43166 1/20 0.50
XDH P47989 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL70470 0.89 ALDH1A1 (0.65) ALDH1A1MAPTKDM4ETDP1NPC1
SCHEMBL4657653 0.86 MEN1 (0.56) ALDH1A1TP53MAPTKDM4EGLA
SCHEMBL1017792 0.86 KDM4E (0.54) ALDH1A1MAPTKDM4ENPC1RAB9A
SCHEMBL10400378 0.83 KDM4E (0.59) ALDH1A1TP53MAPTKDM4ETDP1
SCHEMBL9080431 0.81 KDM4E (0.62) ALDH1A1TP53MAPTKDM4ETDP1
SCHEMBL3767347 0.81 KDM4E (0.62) ALDH1A1TP53MAPTKDM4ETDP1
SCHEMBL30967314 0.81 KDM4E (0.62) ALDH1A1TP53MAPTKDM4ETDP1
SCHEMBL17110515 0.81 ALDH1A1 (0.56) ALDH1A1MAPTKDM4ENPC1RAB9A
SCHEMBL3993408 0.81 ALDH1A1 (0.49) ALDH1A1TP53MAPTKDM4ETDP1
SCHEMBL5393044 0.81 ALDH1A1 (0.64) ALDH1A1TP53MAPTKDM4ETDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1919928-A Polymer electrolyte material based on room temperature fused salt BEIJING INST TECHNOLOGY (CN) 2007-02-28 CN claimed
CN-1585185-A Room-temperature molten salt electrolyte materials NAT HIGH TECHNOLOGIES GREEN MA (CN) 2005-02-23 CN claimed
CN-118580241-A Tetrahydropyrrolo [3,4-c ] pyrazole compound, preparation method and application thereof in medicine 江苏恒瑞医药股份有限公司 2024-09-03 CN disclosed
CN-102613209-A Group of 4-halogenated methyl-1, 2, 3-thiodiazole compounds and preparation method and application thereof UNIV NANKAI 2012-08-01 CN disclosed
CN-101891710-B 4-halogenated methyl-1, 2, 3-thiadiazole compounds, and preparation method and application thereof UNIV NANKAI 2012-07-04 CN disclosed
US-7956070-B2 Piperidines as chemokine modulators (CCR) ASTRAZENECA AB (SE) 2011-06-07 US disclosed
CN-101891710-A 4-halogenated methyl-1, 2, 3-thiadiazole compounds, and preparation method and application thereof UNIV NANKAI 2010-11-24 CN disclosed
CN-101740813-A Ionic liquid compound electrolyte material BEIJING INST TECHNOLOGY 2010-06-16 CN disclosed
CN-101740814-A Ionic liquid electrolyte material BEIJING INST TECHNOLOGY 2010-06-16 CN disclosed
CN-100588685-C Polymer electrolyte material based on room temperature fused salt BEIJING INST TECHNOLOGY 2010-02-10 CN disclosed
CN-101115715-A Pyrrolidine derivatives for the treatment of diseases associated with renin activity NOVARTIS AG (CH) 2008-01-30 CN disclosed
CN-1314160-C Room-temperature molten salt electrolyte materials NAT HIGH TECHNOLOGIES GREEN MA (CN) 2007-05-02 CN disclosed
CN-1938274-A Novel piperidines as chemokine modulators (CCR) ASTRAZENECA AB (SE) 2007-03-28 CN disclosed
CN-1930120-A Process for producing urethane (meth)acrylates and new urethane (meth)acrylates CYTEC SURFACE SPECIALTIES SA (BE) 2007-03-14 CN disclosed
US-20070054924-A1 Novel piperidines as chemokine modulators (ccr) ASTRAZENECA AB (SE) 2007-03-08 US disclosed
CN-1919928-A Polymer electrolyte material based on room temperature fused salt BEIJING INST TECHNOLOGY (CN) 2007-02-28 CN disclosed
EP-1713772-A1 NOVEL PIPERIDINES AS CHEMOKINE MODULATORS (CCR) AstraZeneca AB (SE) 2006-10-25 EP disclosed
WO-2005073192-A1 NOVEL PIPERIDINES AS CHEMOKINE MODULATORS (CCR) ASTRAZENECA AB (SE) 2005-08-11 WO disclosed
CN-1585185-A Room-temperature molten salt electrolyte materials NAT HIGH TECHNOLOGIES GREEN MA (CN) 2005-02-23 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070054924-A1 Novel piperidines as chemokine modulators (ccr) CCR3, CCR1, CCR4 ALDH1A1 994/4885TP53 4872/4885MAPT 4473/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.