Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | KDM5C | P41229 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.46 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70470 | 0.89 | ALDH1A1 (0.65) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL29606273 | 0.86 | TSHR (0.55) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL4462421 | 0.86 | ALDH1A1 (0.57) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL1929461 | 0.86 | ALDH1A1 (0.61) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL1483403 | 0.86 | TSHR (0.55) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL29699657 | 0.83 | KDM4E (0.55) | MAPTLMNAKDM4ESMN1; SMN2TSHR | |
| SCHEMBL820141 | 0.83 | KDM4E (0.55) | MAPTLMNAKDM4ESMN1; SMN2TSHR | |
| SCHEMBL293610 | 0.81 | KDM4E (0.53) | MAPTLMNAKDM4ESMN1; SMN2TSHR | |
| SCHEMBL293611 | 0.81 | KDM4E (0.55) | MAPTLMNAKDM4ESMN1; SMN2TSHR | |
| SCHEMBL1929517 | 0.81 | TSHR (0.50) | MEN1KMT2AMAPTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200270240-A1 | BENZOTHIAZOLE AND PYRIDOTHIAZOLE COMPOUNDS AS SUMO ACTIVATORS | ICAHN SCHOOL MED MOUNT SINAI (US) | 2020-08-27 | — | — | US | disclosed |
| US-20200270240-A1 | BENZOTHIAZOLE AND PYRIDOTHIAZOLE COMPOUNDS AS SUMO ACTIVATORS | ICAHN SCHOOL MED MOUNT SINAI (US) | 2020-08-27 | — | — | US | disclosed |
| EP-3654975-A1 | BENZOTHIAZOLE AND PYRIDOTHIAZOLE COMPOUNDS AS SUMO ACTIVATORS | Icahn School of Medicine at Mount Sinai (US) | 2020-05-27 | — | — | EP | disclosed |
| WO-2019018718-A1 | BENZOTHIAZOLE AND PYRIDOTHIAZOLE COMPOUNDS AS SUMO ACTIVATORS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2019-01-24 | — | — | WO | disclosed |
| WO-2019018718-A1 | BENZOTHIAZOLE AND PYRIDOTHIAZOLE COMPOUNDS AS SUMO ACTIVATORS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2019-01-24 | — | — | WO | disclosed |
| CN-105143228-A | [1,2,4]triazol[4,3-a]pyridine derivate, preparation method therefor or medical application thereof | JIANGSU HANSOH PHARMACEUTICAL | 2015-12-09 | — | — | CN | disclosed |
| EP-1391199-B1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2008-12-10 | — | — | EP | disclosed |
| US-20070088027-A1 | Carboxylic acid derivatives and pharmaceutical compositions comprising the same as an active ingredient | ONO PHARMACEUTICAL CO., LTD. | 2007-04-19 | — | — | US | disclosed |
| US-7179817-B2 | Carboxylic acid derivatives and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-02-20 | — | — | US | disclosed |
| US-20040224941-A1 | Carboxylic acid derivatives and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-11-11 | — | — | US | disclosed |
| EP-1391199-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-02-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200270240-A1 | BENZOTHIAZOLE AND PYRIDOTHIAZOLE COMPOUNDS AS SUMO ACTIVATORS | SUMO2, ATP2A2, ATP2A1 | MEN1 4225/4885KMT2A 1387/4885MAPT 694/4885 |
| US-20070088027-A1 | Carboxylic acid derivatives and pharmaceutical compositions comprising the same as an active ingredient | EDF1, FFAR1, EDNRA | MEN1 1748/4885KMT2A 4772/4885MAPT 1148/4885 |
| US-20040224941-A1 | Carboxylic acid derivatives and drugs containing the same as the active ingredient | EDF1, FFAR1, VCAM1 | MEN1 1352/4885KMT2A 4829/4885MAPT 874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.