Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11552038 | 0.98 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1CYP1A2TP53MAPK1 | |
| SCHEMBL8535478 | 0.84 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1CYP1A2MAPK1LMNA | |
| SCHEMBL9336873 | 0.80 | HRH1 (0.50) | SMN1; SMN2ALDH1A1CYP1A2TP53MAPK1 | |
| SCHEMBL9073359 | 0.80 | HRH1 (0.56) | SMN1; SMN2ALDH1A1CYP1A2TP53MAPK1 | |
| SCHEMBL15671736 | 0.79 | HRH4 (0.44) | SMN1; SMN2ALDH1A1CYP1A2TP53MAPK1 | |
| SCHEMBL2453047 | 0.78 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1CYP1A2TP53MAPK1 | |
| SCHEMBL8422457 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1CYP1A2TP53MAPK1 | |
| SCHEMBL778332 | 0.78 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1CYP1A2TP53MAPK1 | |
| SCHEMBL2242665 | 0.78 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1CYP1A2TP53MAPK1 | |
| SCHEMBL1090112 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1CYP1A2TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174890-B1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2019-03-13 | — | — | EP | disclosed |
| US-9853228-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2017-12-26 | — | — | US | disclosed |
| US-9853228-B2 | Metal complexes | MERCK PATENT GMBH (DE) | 2017-12-26 | — | — | US | disclosed |
| US-20170250353-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2017-08-31 | — | — | US | disclosed |
| US-20170250353-A1 | METAL COMPLEXES | MERCK PATENT GMBH (DE) | 2017-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170250353-A1 | METAL COMPLEXES | SOD1, AP1M1, AP3M1 | SMN1; SMN2 3736/4885ALDH1A1 3721/4885CYP1A2 3647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.