Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19253483 | 0.85 | RAB9A (0.39) | KMT2AGAALMNAMEN1ALDH1A1 | |
| SCHEMBL17801148 | 0.84 | LMNA (0.44) | KMT2AGAALMNAMEN1FAAH | |
| SCHEMBL22449668 | 0.76 | LMNA (0.40) | GRNSORT1KMT2ALMNAMEN1 | |
| SCHEMBL19253526 | 0.73 | NPSR1 (0.39) | GRNSORT1KMT2ALMNAALDH1A1 | |
| SCHEMBL22549420 | 0.72 | LMNA (0.38) | GRNSORT1KMT2ALMNAMEN1 | |
| SCHEMBL31131706 | 0.72 | MET (0.36) | GRNSORT1LMNAALDH1A1MAPT | |
| SCHEMBL19300141 | 0.72 | NPSR1 (0.38) | GRNSORT1LMNAALDH1A1CYP2C19 | |
| SCHEMBL19253406 | 0.72 | NPC1 (0.39) | KMT2ALMNAALDH1A1MAPTCYP2C19 | |
| SCHEMBL358469 | 0.71 | CYP2C9 (0.47) | GRNSORT1LMNAALDH1A1CYP2C19 | |
| SCHEMBL28940409 | 0.70 | GRN (0.37) | GRNSORT1LMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017144995-A1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS | PFIZER INC. (US) | 2017-08-31 | — | — | WO | disclosed |