Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 1/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 5/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31131706 | 0.81 | MET (0.36) | GRNSORT1SMN1; SMN2LMNAMAPT | |
| SCHEMBL17801148 | 0.79 | LMNA (0.44) | SMN1; SMN2LMNAMAPTKDM4E | |
| SCHEMBL19253522 | 0.76 | EGLN1 (0.45) | L3MBTL1P2RY14KDM4EALDH1A1 | |
| SCHEMBL21872450 | 0.73 | RAB9A (0.40) | GRNSORT1L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL22449668 | 0.73 | LMNA (0.40) | GRNSORT1SMN1; SMN2LMNAMAPT | |
| SCHEMBL28130273 | 0.71 | MEN1 (0.49) | L3MBTL1LMNAMAPTHPGDKDM4E | |
| SCHEMBL19300031 | 0.70 | GRN (0.35) | GRNSORT1LMNAMAPTALDH1A1 | |
| SCHEMBL3646146 | 0.70 | MARS1 (0.46) | GRNSORT1L3MBTL1P2RY14MAPT | |
| SCHEMBL22549420 | 0.69 | LMNA (0.38) | GRNSORT1L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL248730 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110267960-B | Substituted pyrazolo [1,5-a ] pyrazine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2022-04-26 | — | — | CN | disclosed |