Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12112006 | 0.77 | TSHR (0.44) | CYP3A4MAPK1TSHRALDH1A1TDP1 | |
| SCHEMBL11309197 | 0.75 | MAPK1 (0.42) | CYP3A4MAPK1TSHRALDH1A1TDP1 | |
| SCHEMBL7298205 | 0.73 | MAPK1 (0.41) | CYP3A4MAPK1TSHRALDH1A1TDP1 | |
| SCHEMBL14123914 | 0.71 | SMN1; SMN2 (0.39) | CYP3A4MAPK1TSHRALDH1A1TDP1 | |
| SCHEMBL7297682 | 0.70 | CYP3A4 (0.46) | CYP3A4MAPK1TSHRALDH1A1TDP1 | |
| Alcohol SCHEMBL10901320 | 0.69 | MEN1 (0.57) | CYP3A4MAPK1TSHRALDH1A1TDP1 | |
| SCHEMBL12112007 | 0.69 | TSHR (0.41) | CYP3A4MAPK1TSHRALDH1A1TDP1 | |
| SCHEMBL12112004 | 0.69 | MAPK1 (0.50) | CYP3A4MAPK1TSHRALDH1A1TDP1 | |
| SCHEMBL4523181 | 0.69 | SLC6A4 (0.52) | CYP3A4MAPK1TSHRALDH1A1TDP1 | |
| SCHEMBL2939873 | 0.69 | MAPK1 (0.50) | CYP3A4MAPK1TSHRALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9850234-B2 | Pyridine derivatives as soft rock inhibitors | REDX PHARMA PLC (GB) | 2017-12-26 | — | — | US | disclosed |
| US-20170247357-A1 | PYRIDINE DERIVATIVES AS SOFT ROCK INHIBITORS | REDX PHARMA PLC (GB) | 2017-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247357-A1 | PYRIDINE DERIVATIVES AS SOFT ROCK INHIBITORS | ROCK1, ROCK2, RHOT2 | CYP3A4 1916/4885MAPK1 164/4885TSHR 3191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.