Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.35 |
| ▸ | ACP3 | P15309 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL210855 | 0.86 | MEN1 (0.38) | ALDH1A1KDM4ERAB9AMEN1KMT2A | |
| SCHEMBL1226951 | 0.84 | MEN1 (0.39) | ALDH1A1KDM4ERAB9AMEN1KMT2A | |
| SCHEMBL13851328 | 0.84 | ALDH1A1 (0.53) | ALDH1A1KDM4ERAB9AMEN1KMT2A | |
| Bromide SCHEMBL3361424 | 0.83 | ALDH1A1 (0.51) | ALDH1A1KDM4ERAB9AMEN1KMT2A | |
| Bromide SCHEMBL918125 | 0.82 | MEN1 (0.38) | BCHEACHEALDH1A1KDM4ERAB9A | |
| SCHEMBL17384186 | 0.80 | ALDH1A1 (0.49) | ALDH1A1KDM4ERAB9AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL600629 | 0.80 | ACP3 (0.38) | ALDH1A1MEN1KMT2AGGPS1ACP3 | |
| Hydrochloric Acid SCHEMBL600596 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL3364505 | 0.78 | MEN1 (0.40) | ALDH1A1KDM4ERAB9AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL602361 | 0.77 | S1PR2 (0.48) | ALDH1A1KDM4ERAB9APOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8786932-B2 | Advanced electrode structures and electrochromic devices | NTERA, INC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20120038967-A1 | ADVANCED ELECTRODE STRUCTURES AND ELECTROCHROMIC DEVICES | NTERA LIMITED (IE) | 2012-02-16 | — | — | US | disclosed |
| EP-2401650-A1 | ADVANCED ELECTRODE STRUCTURES AND ELECTROCHROMIC DEVICES | Ntera, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |