Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.48 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.48 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19302682 | 0.87 | IMPDH2 (0.53) | IMPDH2IMPDH1TRPM2 | |
| SCHEMBL19302914 | 0.87 | TRPM2 (0.51) | IMPDH2IMPDH1TRPM2 | |
| SCHEMBL19302913 | 0.87 | HINT1 (0.53) | TRPM2 | |
| SCHEMBL19302703 | 0.87 | IMPDH2 (0.51) | IMPDH2IMPDH1TRPM2 | |
| SCHEMBL19302841 | 0.85 | TRPM2 (0.53) | TRPM2 | |
| SCHEMBL19302910 | 0.85 | IMPDH2 (0.47) | IMPDH2IMPDH1TRPM2 | |
| SCHEMBL19302911 | 0.84 | — | — | |
| SCHEMBL19302968 | 0.82 | IMPDH2 (0.48) | IMPDH2IMPDH1TRPM2 | |
| SCHEMBL19302806 | 0.81 | TRPM2 (0.64) | TRPM2 | |
| SCHEMBL19302871 | 0.80 | GNMT (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017059411-A9 | INHIBITORS OF MENAQUINONE BIOSYNTHESIS | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2017-08-31 | — | — | WO | disclosed |