Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.46 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 4/20 | 0.38 |
| ▸ | TYK2 | P29597 | 4/20 | 0.38 |
| ▸ | JAK3 | P52333 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16492684 | 0.83 | KEAP1 (0.41) | PTGS1PTGS2ALOX5APFEN1HTT | |
| SCHEMBL23758136 | 0.79 | BRD4 (0.36) | BRD4JAK2JAK1JAK3PTGS1 | |
| SCHEMBL19303539 | 0.78 | HPGD (0.45) | BRD4PSIP1JAK2JAK1TYK2 | |
| SCHEMBL15108222 | 0.74 | PSIP1 (0.53) | BRD4PSIP1JAK2JAK1TYK2 | |
| SCHEMBL18595670 | 0.73 | PSIP1 (0.45) | BRD4PSIP1JAK2JAK1TYK2 | |
| SCHEMBL18010004 | 0.73 | PSIP1 (0.49) | BRD4PSIP1JAK2JAK1TYK2 | |
| SCHEMBL19303542 | 0.72 | PSIP1 (0.51) | BRD4PSIP1HPGDLMNAHSD17B10 | |
| SCHEMBL26789805 | 0.72 | RAB9A (0.56) | HPGDLMNAHSD17B10SMN1; SMN2TP53 | |
| SCHEMBL25215031 | 0.71 | NOS3 (0.31) | SMN1; SMN2NPC1 | |
| SCHEMBL17336598 | 0.70 | RAB9A (0.42) | HPGDHSD17B10SMN1; SMN2TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017147526-A1 | PI-KINASE INHIBITORS WITH ANTI-INFECTIVE ACTIVITY | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2017-08-31 | — | — | WO | disclosed |