SCHEMBL193085

SCHEMBL193085

CC(=O)C1=NOC(c2c(F)cccc2F)C1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.38
KIF11 P52732 3/20 0.36
RAB9A P51151 3/20 0.34
NPC1 O15118 2/20 0.34
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
LMNA P02545 2/20 0.33
ALDH1A1 P00352 1/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
MIF P14174 1/20 0.33
CYP3A4 P08684 1/20 0.32
CYP2C19 P33261 1/20 0.32
RECQL P46063 1/20 0.32
CES2 O00748 1/20 0.32
CES1 P23141 1/20 0.32
NOTUM Q6P988 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19525865 1.00 POLB (0.38) POLBKIF11RAB9ANPC1MEN1
SCHEMBL19525866 0.84 POLB (0.37) POLBKIF11RAB9ANPC1MEN1
SCHEMBL10163553 0.84 POLB (0.35) POLBKIF11RAB9ANPC1MEN1
SCHEMBL192351 0.84 POLB (0.37) POLBKIF11RAB9ANPC1MEN1
SCHEMBL192955 0.81 POLB (0.35) POLBRAB9ANPC1MEN1KMT2A
SCHEMBL19525864 0.81 POLB (0.35) POLBRAB9ANPC1MEN1KMT2A
SCHEMBL564213 0.81 POLB (0.35) POLBRAB9ANPC1MEN1KMT2A
SCHEMBL20718925 0.76 TSHR (0.54) POLBALDH1A1TSHRCYP3A4CYP2C19
SCHEMBL2740662 0.76 TEAD1 (0.35) POLBMEN1KMT2ALMNAALDH1A1
SCHEMBL12305010 0.76 TEAD1 (0.35) POLBMEN1KMT2ALMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120943793-A Preparation method of 1- [5- (2, 6-difluorophenyl) -4, 5-dihydro-isoxazol-3-yl ] ethanone compound or salt thereof 永农生物科学有限公司 2025-11-14 CN disclosed
CN-120943793-A Preparation method of 1- [5- (2, 6-difluorophenyl) -4, 5-dihydro-isoxazol-3-yl ] ethanone compound or salt thereof 永农生物科学有限公司 2025-11-14 CN disclosed
CN-114685481-A Preparation method of oxathiapiprolin 南通泰禾化工股份有限公司 2022-07-01 CN disclosed
US-10604495-B2 Process for preparing substituted phenylisoxazoline derivatives BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-03-31 US disclosed
EP-3265446-B1 PROCESS FOR PREPARING SUBSTITUTED PHENYLISOXAZOLINE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2019-08-14 EP disclosed
US-10189799-B2 Process for preparing substituted phenylisoxazoline derivatives BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-01-29 US disclosed
US-20190016691-A1 PROCESS FOR PREPARING SUBSTITUTED PHENYLISOXAZOLINE DERIVATIVES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-01-17 US disclosed
US-20180030002-A1 Process for preparing substituted phenylisoxazoline derivatives BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-02-01 US disclosed
US-20180030002-A1 Process for preparing substituted phenylisoxazoline derivatives BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-02-01 US disclosed
US-9090604-B2 Fungicidal azocyclic amides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-07-28 US disclosed
US-20120309752-A1 FUNGICIDAL HETEROCYCLIC COMPOUNDS E I DU PONT DE NEMOURS AND COMPANY (US) 2012-12-06 US disclosed
EP-2521450-A1 FUNGICIDAL HETEROCYCLIC COMPOUNDS E.I. Du Pont De Nemours And Company (US) 2012-11-14 EP disclosed
EP-2402332-A2 Fungicidal heterocyclic compounds E.I. Du Pont De Nemours And Company (US) 2012-01-04 EP disclosed
US-20110224258-A1 FUNGICIDAL HETEROCYCLIC COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (DE) 2011-09-15 US disclosed
EP-2358709-A2 FUNGICIDAL HETEROCYCLIC COMPOUNDS E. I. du Pont de Nemours and Company (US) 2011-08-24 EP disclosed
WO-2011085170-A1 FUNGICIDAL HETEROCYCLIC COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2011-07-14 WO disclosed
EP-2260032-A2 FUNGICIDAL HETERCYCLIC COMPOUNDS E. I. du Pont de Nemours and Company (US) 2010-12-15 EP disclosed
US-20100292275-A1 FUNGICIDAL HETEROCYCLIC COMPOUNDS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2010-11-18 US disclosed
WO-2010065579-A2 FUNGICIDAL HETEROCYCLIC COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2010-06-10 WO disclosed
WO-2009094445-A2 FUNGICIDAL HETERCYCLIC COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-07-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10189799-B2 Process for preparing substituted phenylisoxazoline derivatives CYP3A7, CYP3A4, CYP4X1 POLB 1028/4885KIF11 1432/4885RAB9A 3725/4885
US-20110224258-A1 FUNGICIDAL HETEROCYCLIC COMPOUNDS NOX1, XDH, CBR1 POLB 4340/4885KIF11 3620/4885RAB9A 664/4885
US-10604495-B2 Process for preparing substituted phenylisoxazoline derivatives CYP3A7, CYP3A4, CYP4X1 POLB 1028/4885KIF11 1432/4885RAB9A 3725/4885
US-20100292275-A1 FUNGICIDAL HETEROCYCLIC COMPOUNDS CYP1B1, CBR1, NOX1 POLB 4093/4885KIF11 4217/4885RAB9A 863/4885
US-20190016691-A1 PROCESS FOR PREPARING SUBSTITUTED PHENYLISOXAZOLINE DERIVATIVES CYP3A7, CYP3A4, CYP4X1 POLB 1028/4885KIF11 1432/4885RAB9A 3725/4885
US-20120309752-A1 FUNGICIDAL HETEROCYCLIC COMPOUNDS CYP1B1, NOX3, CYP1A1 POLB 4536/4885KIF11 4312/4885RAB9A 1177/4885
US-20180030002-A1 Process for preparing substituted phenylisoxazoline derivatives CYP3A7, CYP3A4, CYP4X1 POLB 1028/4885KIF11 1432/4885RAB9A 3725/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.