Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11811790 | 0.78 | CYP3A4 (0.46) | ALDH1A1MAPK1ALOX15CYP3A4TP53 | |
| SCHEMBL31357831 | 0.77 | HRH3 (0.38) | ALDH1A1GAAKMT2AMAPTKDM4E | |
| SCHEMBL7406313 | 0.76 | GAA (0.59) | ALDH1A1MAPK1ALOX15CYP3A4TP53 | |
| SCHEMBL10956325 | 0.76 | ALDH1A1 (0.44) | ALDH1A1MAPK1ALOX15CYP3A4TP53 | |
| SCHEMBL9566865 | 0.76 | ALOX15 (0.42) | ALDH1A1MAPK1ALOX15TDP1GAA | |
| SCHEMBL15281583 | 0.74 | MAPT (0.42) | ALDH1A1MAPK1TDP1GAAKMT2A | |
| SCHEMBL214484 | 0.74 | ALDH1A1 (0.54) | ALDH1A1MAPK1ALOX15CYP3A4TP53 | |
| SCHEMBL8644984 | 0.74 | CRHR1 (0.46) | ALDH1A1MAPK1ALOX15CYP3A4TP53 | |
| SCHEMBL21904876 | 0.73 | ALDH1A1 (0.37) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9788673 | 0.73 | ALDH1A1 (0.52) | ALDH1A1MAPK1ALOX15CYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240116857-A1 | QUATERNARY AMMONIUM COMPOUNDS AS ANTIMICROBIALS | SAINT LOUIS UNIVERSITY (US) | 2024-04-11 | — | — | US | disclosed |
| US-8609652-B2 | Method of administering a methylene blue-curcumin analog for the treatment of alzheimer's disease | DePuy Synthes Products, LLC (US) | 2013-12-17 | — | — | US | disclosed |
| US-20110130392-A1 | Method of Administering a Methylene Blue - Curcumin Analog for the Treatment of Alzheimer's Disease | DEPUY SPINE, LLC | 2011-06-02 | — | — | US | disclosed |
| US-7906643-B2 | Methylene blue-curcumin analog for the treatment of Alzheimer's Disease | CODMAN & SHURTLEFF, INC. (US) | 2011-03-15 | — | — | US | disclosed |
| US-20100190978-A1 | METHYLENE BLUE - CURCUMIN ANALOG FOR THE TREATMENT OF ALZHEIMER'S DISEASE | CODMAN & SHURTLEFF, INC. | 2010-07-29 | — | — | US | disclosed |
| WO-2010085739-A1 | METHYLENE BLUE - CURCUMIN ANALOG FOR THE TREATMENT OF ALZHEIMER'S DISEASE | CODMAN & SHURTLEFF, INC. (US) | 2010-07-29 | — | — | WO | disclosed |
| US-7723515-B1 | Methylene blue—curcumin analog for the treatment of alzheimer's disease | CODMAN & SHURTLEFF, INC. (US) | 2010-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190978-A1 | METHYLENE BLUE - CURCUMIN ANALOG FOR THE TREATMENT OF ALZHEIMER'S DISEASE | APP, PSEN2, MAPT | ALDH1A1 441/4885MAPK1 3878/4885ALOX15 1034/4885 |
| US-20110130392-A1 | Method of Administering a Methylene Blue - Curcumin Analog for the Treatment of Alzheimer's Disease | APP, PSEN2, MAPT | ALDH1A1 438/4885MAPK1 4307/4885ALOX15 857/4885 |
| US-20240116857-A1 | QUATERNARY AMMONIUM COMPOUNDS AS ANTIMICROBIALS | ABCC1, ARG1, SLC11A2 | ALDH1A1 2841/4885MAPK1 2049/4885ALOX15 3755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.