Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18537879 | 0.83 | LMNA (0.57) | IRAK4NPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL29500516 | 0.83 | LMNA (0.57) | IRAK4NPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL31154057 | 0.81 | MEN1 (0.54) | IRAK4NPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL4578043 | 0.80 | IRAK4 (0.49) | IRAK4NPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL17488032 | 0.80 | RAB9A (0.67) | IRAK4NPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL6990673 | 0.80 | MEN1 (0.51) | IRAK4NPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL5743889 | 0.79 | SMN1; SMN2 (0.74) | IRAK4NPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL25956596 | 0.78 | IRAK4 (0.83) | IRAK4NPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL19329541 | 0.77 | RIPK1 (0.54) | IRAK4NPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL418190 | 0.75 | SMN1; SMN2 (0.52) | IRAK4NPC1SMN1; SMN2RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017153952-A1 | 5-SULFAMOYL-2-HYDROXYBENZAMIDE DERIVATIVES | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-09-14 | — | — | WO | disclosed |