Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 2/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31576819 | 0.83 | ALOX5 (0.76) | PTGESALOX5PTGS1PTGS2SMPD1 | |
| SCHEMBL9578229 | 0.83 | ALOX5 (0.76) | PTGESALOX5PTGS1PTGS2SMPD1 | |
| SCHEMBL13893459 | 0.80 | PTGES (0.54) | PTGESALOX5PTGS1PTGS2SMPD1 | |
| SCHEMBL22139408 | 0.79 | XDH (0.45) | PTGESALOX5PTGS1PTGS2MEN1 | |
| SCHEMBL5844884 | 0.78 | PTGES (0.36) | PTGESALOX5PTGS1PTGS2MEN1 | |
| SCHEMBL2649487 | 0.78 | KDM4E (0.39) | PTGESALOX5PTGS1PTGS2MEN1 | |
| SCHEMBL13978665 | 0.75 | THRB (0.45) | ALOX5PTGS1MEN1KMT2ACYP3A4 | |
| SCHEMBL1258932 | 0.74 | CYP3A4 (0.64) | PTGESALOX5PTGS1PTGS2MEN1 | |
| SCHEMBL29495886 | 0.74 | ALOX5 (1.00) | PTGESALOX5PTGS1PTGS2CTSL | |
| SCHEMBL11107375 | 0.73 | KDM4E (0.43) | ALOX5PTGS1PTGS2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130447-A1 | Production of hop extracts having oestrogenic and antiproliferative bioactivity | MAES FRANCIS | 2011-06-02 | — | — | US | disclosed |
| EP-1727555-B1 | PRODUCTION OF HOP EXTRACTS HAVING OESTROGENIC AND ANTIPROLIFERATIVE BIOACTIVITY | METAGENICS BELGIUM BVBA (BE) | 2009-04-29 | — | — | EP | disclosed |
| WO-2007053915-A2 | NARINGENIN DERIVATIVES WITH SELECTIVITY ON ERS | UNIVERSITEIT GENT (BE) | 2007-05-18 | — | — | WO | disclosed |
| US-20070110835-A1 | Method for the production of enriched hop extracts having combined oestrogenic and antiproliferative bioactivity | METAGENICS BELGIUM BVBA (BE) | 2007-05-17 | — | — | US | disclosed |
| EP-1727555-A1 | PRODUCTION OF HOP EXTRACTS HAVING OESTROGENIC AND ANTIPROLIFERATIVE BIOACTIVITY | Biodynamics (BE) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005058336-A1 | PRODUCTION OF HOP EXTRACTS HAVING OESTROGENIC AND ANTIPROLIFERATIVE BIOACTIVITY | BIODYNAMICS (BE) | 2005-06-30 | — | — | WO | disclosed |
| EP-1543834-A1 | Production of hop extracts having oestrogenic and antiproliferative bioactivity | Biodynamics (BE) | 2005-06-22 | — | — | EP | disclosed |
| US-5234951-A | Anti-ulcer agent comprising chalcone derivative | TSUMURA JUNTENDO, INC. (JP) | 1993-08-10 | — | — | US | disclosed |
| US-5106871-A | Reduced side effects | TSUMURA & CO. (JP) | 1992-04-21 | — | — | US | disclosed |
| EP-0292576-A1 | ANTI-ULCEROUS AGENT CONTAINING CHALCONE DERIVATIVE AS EFFECTIVE INGREDIENT AND NOVEL CHALCONE DERIVATIVES | TSUMURA & CO. (JP) | 1988-11-30 | — | — | EP | disclosed |