Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200546 | 0.73 | BRPF1 (0.39) | TDP1L3MBTL1ATMALDH1A1KDM4E | |
| SCHEMBL28165403 | 0.71 | L3MBTL1 (0.54) | TDP1L3MBTL1ATMALDH1A1KDM4E | |
| SCHEMBL21647516 | 0.66 | KMT2A (0.42) | L3MBTL1ALDH1A1KDM4EHTTALOX15 | |
| SCHEMBL21647585 | 0.64 | KDM4E (0.41) | L3MBTL1ALDH1A1KDM4EHTT | |
| SCHEMBL29715836 | 0.64 | KDM4E (0.41) | L3MBTL1ALDH1A1KDM4EHTT | |
| SCHEMBL13819109 | 0.63 | PARG (0.54) | ALDH1A1KDM4EHTT | |
| SCHEMBL23049658 | 0.62 | PHGDH (0.39) | — | |
| SCHEMBL27969744 | 0.61 | ALDH1A1 (0.34) | ALDH1A1KDM4E | |
| SCHEMBL12926011 | 0.61 | MEN1 (0.43) | TDP1ALDH1A1KDM4E | |
| SCHEMBL28236134 | 0.61 | L3MBTL1 (0.54) | TDP1L3MBTL1ATMALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156181-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |