Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.59 |
| ▸ | PTPN5 | P54829 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.54 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CCR4 | P51679 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5231184 | 0.82 | MAPT (0.68) | LMNAMAPTPTPN2PTPN1PTPN5 | |
| SCHEMBL7573917 | 0.80 | MAPT (0.64) | LMNAMAPTPTPN2PTPN1PTPN5 | |
| SCHEMBL29118849 | 0.80 | MAPT (0.64) | LMNAMAPTPTPN2PTPN1PTPN5 | |
| SCHEMBL7569591 | 0.80 | MAPT (0.68) | LMNAMAPTPTPN2PTPN1PTPN5 | |
| SCHEMBL7573063 | 0.79 | MAPT (0.63) | LMNAMAPTPTPN2PTPN1PTPN5 | |
| SCHEMBL29031239 | 0.77 | MAPT (0.58) | LMNAMAPTPTPN2PTPN1PTPN5 | |
| SCHEMBL7578134 | 0.77 | LMNA (0.71) | LMNAMAPTPTPN2PTPN1PTPN5 | |
| SCHEMBL5229467 | 0.76 | MEN1 (0.60) | LMNAMAPTPTPN2PTPN1PTPN5 | |
| SCHEMBL5226104 | 0.75 | SMN1; SMN2 (0.63) | LMNAMAPTPTPN2PTPN1PTPN5 | |
| SCHEMBL7573143 | 0.75 | ALDH1A1 (0.64) | LMNAMAPTPTPN2PTPN1PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9757375-B2 | Compounds that inhibit human DNA ligases and methods of treating cancer | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2017-09-12 | — | — | US | disclosed |