Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 6/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.59 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.56 |
| ▸ | PTPN5 | P54829 | 4/20 | 0.56 |
| ▸ | HSPD1 | P10809 | 3/20 | 0.56 |
| ▸ | HSPE1 | P61604 | 3/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 2/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5231184 | 0.86 | MAPT (0.68) | MAPTLMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7573029 | 0.84 | PTGES2 (0.74) | MAPTLMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7569591 | 0.83 | MAPT (0.68) | MAPTLMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL29118849 | 0.83 | MAPT (0.64) | MAPTLMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7573917 | 0.83 | MAPT (0.64) | MAPTLMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2157782 | 0.80 | PTPN2 (0.53) | MAPTLMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7573985 | 0.79 | PTGES2 (0.68) | MAPTLMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL19334352 | 0.79 | LMNA (0.67) | MAPTLMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5229467 | 0.79 | MEN1 (0.60) | MAPTLMNAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2841125 | 0.79 | MAPT (0.55) | MAPTLMNAKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230257373-A1 | QUORUM SENSING INHIBITORS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH | 2023-08-17 | — | — | US | disclosed |
| US-20230257373-A1 | QUORUM SENSING INHIBITORS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH | 2023-08-17 | — | — | US | disclosed |
| US-20230257373-A1 | QUORUM SENSING INHIBITORS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH | 2023-08-17 | — | — | US | disclosed |
| EP-4196108-A1 | QUORUM SENSING INHIBITORS AND METHODS OF USE | The Trustees of Indiana University (US) | 2023-06-21 | — | — | EP | disclosed |
| WO-2022036282-A1 | QUORUM SENSING INHIBITORS AND METHODS OF USE | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2022-02-17 | — | — | WO | disclosed |
| WO-2022036282-A1 | QUORUM SENSING INHIBITORS AND METHODS OF USE | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2022-02-17 | — | — | WO | disclosed |
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257373-A1 | QUORUM SENSING INHIBITORS AND METHODS OF USE | PGLS, BLVRB, CGAS | MAPT 4878/4885LMNA 4498/4885KMT2A 4067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.