Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.51 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5231184 | 0.86 | MAPT (0.68) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7573917 | 0.83 | MAPT (0.64) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL29118849 | 0.83 | MAPT (0.64) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7573063 | 0.83 | MAPT (0.63) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19334352 | 0.80 | LMNA (0.67) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5229467 | 0.80 | MEN1 (0.60) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5226104 | 0.79 | SMN1; SMN2 (0.63) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL12334078 | 0.78 | RORA (0.62) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL18292336 | 0.78 | MAPT (0.56) | MAPTLMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7578134 | 0.78 | LMNA (0.71) | MAPTLMNASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |