Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19334755 | 0.84 | ALDH1A1 (0.44) | MEN1HTTKMT2AKDM4EALDH1A1 | |
| SCHEMBL19334766 | 0.82 | MAPT (0.42) | MEN1HTTKMT2AKDM4EALDH1A1 | |
| SCHEMBL19334753 | 0.82 | ALDH1A1 (0.39) | MEN1HTTKMT2AKDM4EALDH1A1 | |
| SCHEMBL15143562 | 0.81 | ACHE (0.43) | KDM4EALDH1A1HPGDAKR1B1MAPK14 | |
| SCHEMBL16587501 | 0.70 | MEN1 (0.46) | MEN1KMT2AALDH1A1HSD17B3AKR1B1 | |
| SCHEMBL12016675 | 0.69 | EPHX2 (0.44) | MEN1HTTKMT2AKDM4EALDH1A1 | |
| SCHEMBL13871409 | 0.69 | EPHX2 (0.53) | MEN1HTTKMT2AKDM4EALDH1A1 | |
| SCHEMBL5766444 | 0.68 | KDM4E (0.46) | MEN1HTTKMT2AKDM4EALDH1A1 | |
| SCHEMBL11873711 | 0.67 | ELANE (0.51) | MEN1HTTKMT2AKDM4EALDH1A1 | |
| SCHEMBL86191 | 0.67 | ELANE (0.51) | MEN1HTTKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9758515-B2 | Substituted polycyclic carbamoyl pyridone derivative prodrug | SHIONOGI & CO., LTD. (JP) | 2017-09-12 | — | — | US | disclosed |