Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | DHODH | Q02127 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.58 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.56 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.56 |
| ▸ | GRM5 | P41594 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.51 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16330055 | 0.84 | POLB (0.72) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL15290422 | 0.81 | HPGD (0.80) | NPC1RAB9ADHODHMEN1KMT2A | |
| SCHEMBL14817806 | 0.80 | ALDH1A1 (0.65) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL13053955 | 0.78 | NPC1 (0.62) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL10212149 | 0.78 | NPC1 (0.62) | NPC1RAB9ADHODHMEN1KMT2A | |
| SCHEMBL29788136 | 0.78 | KDM4E (0.55) | NPC1RAB9AHPGDLMNASMN1; SMN2 | |
| SCHEMBL2040639 | 0.76 | FFAR2 (0.51) | NPC1RAB9ADHODHMEN1KMT2A | |
| SCHEMBL29788091 | 0.76 | FFAR2 (0.51) | NPC1RAB9ADHODHMEN1KMT2A | |
| SCHEMBL11769542 | 0.76 | POLB (0.77) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL30288146 | 0.76 | POLB (0.77) | NPC1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291352-B1 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | CENTRE NAT RECH SCIENT (FR) | 2017-09-13 | — | — | EP | disclosed |