Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 6/20 | 0.39 |
| ▸ | JAK1 | P23458 | 5/20 | 0.39 |
| ▸ | TYK2 | P29597 | 4/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28079387 | 0.81 | L3MBTL1 (0.58) | TDP1L3MBTL1LCKNPY5RADORA3 | |
| SCHEMBL12146723 | 0.71 | TDP1 (0.48) | TDP1L3MBTL1LCKNPY5RADORA3 | |
| SCHEMBL12146715 | 0.71 | TDP1 (0.48) | TDP1L3MBTL1LCKNPY5RADORA3 | |
| SCHEMBL28079612 | 0.69 | TDP1 (0.49) | TDP1L3MBTL1MAPK1LCKNPY5R | |
| SCHEMBL12146721 | 0.69 | TDP1 (0.46) | TDP1L3MBTL1LCKNPY5RADORA3 | |
| SCHEMBL1934242 | 0.69 | JAK1 (0.59) | MAPK1ADORA3ADORA2AADORA1JAK2 | |
| SCHEMBL14565645 | 0.69 | HPGD (0.66) | TDP1L3MBTL1POLBMAPT | |
| SCHEMBL14565646 | 0.69 | HPGD (0.66) | TDP1L3MBTL1POLBMAPT | |
| SCHEMBL28638010 | 0.68 | PDE10A (0.46) | TDP1L3MBTL1PDE10ARAF1 | |
| SCHEMBL19732549 | 0.67 | TDP1 (0.46) | TDP1L3MBTL1LCKNPY5RADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2506716-A1 | NOVEL TRICYCLIC COMPOUNDS | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068881-A1 | NOVEL TRICYCLIC COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |