Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.57 |
| ▸ | BBOX1 | O75936 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CDC25A | P30304 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL1934637 | 0.97 | LMNA (0.60) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL5445163 | 0.95 | LMNA (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL9447071 | 0.95 | LMNA (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL9447029 | 0.95 | LMNA (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL7646166 | 0.93 | CYP3A4 (0.62) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL316335 | 0.92 | MEN1 (0.60) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL136984 | 0.92 | LMNA (0.60) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL9447084 | 0.90 | LMNA (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL9447044 | 0.90 | LMNA (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL7782025 | 0.90 | LMNA (0.57) | LMNAMEN1KMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180192641-A1 | Compositions and Methods for Preservation of Materials in the Amorphous State | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-07-12 | — | — | US | claimed |
| US-9930883-B2 | Compositions and methods for preservation of materials in the amorphous state | UNIVERSITY OF NORTH CAROLLINA CHARLOTTE (US) | 2018-04-03 | — | — | US | claimed |
| US-20160165879-A1 | Compositions and Methods for Preservation of Materials in the Amorphous State | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-06-16 | — | — | US | claimed |
| US-12635684-B2 | Methods and compositions for biopreservation | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 2026-05-26 | — | — | US | disclosed |
| US-20240415112-A1 | LIGHT ASSISTED DRYING METHODS, DEVICES, AND SYSTEMS FOR THE PREPARATION OF BIOLOGICS FOR PRESERVATION AND STORAGE | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | 2024-12-19 | — | — | US | disclosed |
| US-20240049702-A1 | METHODS AND COMPOSITIONS FOR BIOPRESERVATION | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | 2024-02-15 | — | — | US | disclosed |
| US-11849722-B2 | Methods and compositions for biopreservation | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE NC (US) | 2023-12-26 | — | — | US | disclosed |
| CN-114938650-B | Polyurethane or polyurethane urea, antithrombotic coating agent, antithrombotic medical device, and method for producing same | 第一工业制药株式会社 | 2023-09-26 | — | — | CN | disclosed |
| US-20230100493-A1 | POLYURETHANE OR POLYURETHANE UREA, ANTITHROMBOGENIC COATING AGENT, ANTITHROMBOGENIC MEDICAL TOOL, AND PRODUCTION METHOD | DKS CO. LTD. (JP) | 2023-03-30 | — | — | US | disclosed |
| EP-4091644-A1 | POLYURETHANE OR POLYURETHANE UREA, ANTITHROMBOGENIC COATING AGENT, ANTITHROMBOGENIC MEDICAL TOOL, AND PRODUCTION METHOD | DKS Co. Ltd. (JP) | 2022-11-23 | — | — | EP | disclosed |
| CN-114938650-A | Polyurethane or polyurethane urea, antithrombotic coating agent, antithrombotic medical device, and method for producing same | 第一工业制药株式会社 | 2022-08-23 | — | — | CN | disclosed |
| WO-2011069037-A2 | STABILIZATION AND STORAGE OF BIOLOGICAL PHARMACEUTICAL COMPOSITIONS | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 2011-06-09 | — | — | WO | disclosed |
| EP-2264119-A1 | High density phosphate brines and methods for making and using same | Clearwater International LLC (US) | 2010-12-22 | — | — | EP | disclosed |
| US-20100305010-A1 | HIGH DENSITY PHOSPHATE BRINES AND METHODS FOR MAKING AND USING SAME | CLEARWATER INTERNATIONAL, LLC (US) | 2010-12-02 | — | — | US | disclosed |
| US-7566686-B2 | Shale inhibition additive for oil/gas down hole fluids and methods for making and using same | CLEARWATER INTERNATIONAL, LLC (US) | 2009-07-28 | — | — | US | disclosed |
| US-20080039345-A1 | Shale inhibition additive for oil/gas down hole fluids and methods for making and using same | CLEARWATER INTERNATIONAL, L.L.C. | 2008-02-14 | — | — | US | disclosed |
| US-7268100-B2 | Shale inhibition additive for oil/gas down hole fluids and methods for making and using same | CLEARWATER INTERNATIONAL, LLC (US) | 2007-09-11 | — | — | US | disclosed |
| US-20060194700-A1 | Corrosion inhibitor systems for low, moderate and high temperature fluids and methods for making and using same | WEATHERFORD/LAMB | 2006-08-31 | — | — | US | disclosed |
| US-20060153912-A1 | Choline ascorbate formulations | BASF AKTIENGESELLSCHAFT (DE) | 2006-07-13 | — | — | US | disclosed |
| US-20060116296-A1 | Shale Inhibition additive for oil/gas down hole fluids and methods for making and using same | CLEARWATER INTERNATIONAL, L.L.C. | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12635684-B2 | Methods and compositions for biopreservation | IGFBP1, IGFBP2, IL36G | ADORA3 4501/4885LMNA 887/4885MEN1 1781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.