Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2559276 | 0.76 | KDR (0.42) | — | |
| SCHEMBL18586553 | 0.73 | ALDH1A1 (0.35) | NPC1MAPTRAB9AATMSMN1; SMN2 | |
| SCHEMBL2563617 | 0.71 | RAB9A (0.69) | NPC1MAPTRAB9AATMSMN1; SMN2 | |
| SCHEMBL29956895 | 0.71 | HRH4 (0.38) | — | |
| SCHEMBL2556317 | 0.70 | PIK3CA (0.35) | MAPTL3MBTL1CDC7CDK2ROCK1 | |
| SCHEMBL20067383 | 0.67 | ENPP2 (0.36) | — | |
| SCHEMBL15330702 | 0.67 | ALDH1A1 (0.41) | NPC1MAPTRAB9AATMSMN1; SMN2 | |
| SCHEMBL956317 | 0.67 | CCR1 (0.48) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29955389 | 0.67 | CCR1 (0.48) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15845752 | 0.66 | HSD11B1 (0.42) | MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017161145-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE AND/OR EPX | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-21 | — | — | WO | disclosed |