Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | KIF11 | P52732 | 3/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30076092 | 0.91 | RORC (0.45) | RORCEPHX2KIF11TTRKDM4E | |
| SCHEMBL19360581 | 0.89 | RORC (0.53) | RORCEPHX2TTRRBP4IDH1 | |
| SCHEMBL19360314 | 0.88 | RORC (0.65) | RORCC5AR1PPARG | |
| SCHEMBL30076050 | 0.88 | RORC (0.52) | RORCEPHX2KIF11ALDH1A1RBP4 | |
| SCHEMBL19360425 | 0.88 | RORC (0.52) | RORCEPHX2KIF11ALDH1A1RBP4 | |
| SCHEMBL19360540 | 0.82 | RORC (0.45) | RORCEPHX2KDM4EALDH1A1IDH1 | |
| SCHEMBL18440466 | 0.81 | IDH1 (0.49) | RORCIDH1L3MBTL1 | |
| SCHEMBL19360521 | 0.80 | RORC (0.48) | RORCEPHX2KIF11ALDH1A1PPARG | |
| SCHEMBL19360368 | 0.79 | RORC (0.63) | RORCEPHX2KIF11PPARG | |
| SCHEMBL19360442 | 0.78 | RORC (0.83) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109963836-B | Deuterium atom substituted indole carboxamide derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-107531679-B | Aromatic amide derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-07-02 | — | — | CN | disclosed |
| US-20200277278-A1 | Deuterium Atom-Substituted Indole Formamide Derivative, Preparation Method Therefor, and Medical Applications Thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2020-09-03 | — | — | US | disclosed |
| US-20200277278-A1 | Deuterium Atom-Substituted Indole Formamide Derivative, Preparation Method Therefor, and Medical Applications Thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2020-09-03 | — | — | US | disclosed |
| EP-3683206-A1 | DEUTERIUM ATOM-SUBSTITUTED INDOLE FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL APPLICATIONS THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2020-07-22 | — | — | EP | disclosed |
| CN-109963836-A | Indole carboxamides analog derivative, preparation method and its application in medicine that D-atom replaces | 江苏恒瑞医药股份有限公司 | 2019-07-02 | — | — | CN | disclosed |
| WO-2019052440-A1 | DEUTERIUM ATOM-SUBSTITUTED INDOLE FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL APPLICATIONS THEREOF | 江苏恒瑞医药股份有限公司 | 2019-03-21 | — | — | WO | disclosed |
| CN-107531679-A | Aromatic amides analog derivative, its preparation method and its application in medicine | 江苏恒瑞医药股份有限公司 | 2018-01-02 | — | — | CN | disclosed |
| WO-2017157332-A1 | AROMATIC AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATIONS THEREOF | 江苏恒瑞医药股份有限公司 | 2017-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200277278-A1 | Deuterium Atom-Substituted Indole Formamide Derivative, Preparation Method Therefor, and Medical Applications Thereof | RORA, RORB, RORC | RORC 3/4885EPHX2 2726/4885KIF11 562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.