Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 4/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19364826 | 0.88 | FAAH (0.42) | FAAHNPY5RKMT2AGSK3BDYRK1A | |
| SCHEMBL19670319 | 0.88 | FAAH (0.42) | FAAHNPY5RKMT2AGSK3BDYRK1A | |
| SCHEMBL19670235 | 0.86 | GSK3B (0.36) | FAAHKMT2AGSK3BKARS1DYRK1A | |
| SCHEMBL19365761 | 0.86 | MAPT (0.37) | FAAHKMT2AGRM5GSK3BKARS1 | |
| SCHEMBL19364899 | 0.85 | ALOX15 (0.38) | GSK3BCDK5GSK3ADYRK1A | |
| SCHEMBL17618621 | 0.84 | FAAH (0.39) | FAAHSCN9ANPY5RKMT2AGRM5 | |
| SCHEMBL19670370 | 0.84 | P2RX7 (0.38) | KMT2ACDK8 | |
| SCHEMBL19365582 | 0.83 | GSK3B (0.39) | FAAHKMT2AGSK3BDYRK1A | |
| SCHEMBL19670325 | 0.83 | GSK3B (0.39) | FAAHKMT2AGSK3BDYRK1A | |
| SCHEMBL19365464 | 0.81 | TRPV1 (0.39) | FAAHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |