Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365370 | 0.87 | PTGS1 (0.41) | KMT2ARAB9AMEN1NPC1 | |
| SCHEMBL19865071 | 0.84 | HTR2C (0.47) | RAB9ANPC1HIF1AMAPTSMN1; SMN2 | |
| SCHEMBL19865058 | 0.83 | GRM5 (0.39) | KDM4EFFAR2 | |
| SCHEMBL19365751 | 0.83 | GSK3B (0.38) | KDM4EFAAHMAPTGSK3BDYRK1A | |
| SCHEMBL19365270 | 0.82 | WNT3A (0.40) | GSK3BDYRK1A | |
| SCHEMBL19364888 | 0.81 | WNT3A (0.39) | FAAHHIF1AMAPTGSK3BDYRK1A | |
| SCHEMBL16237541 | 0.79 | KMT2A (0.38) | KMT2AKDM4ERAB9AMEN1CHEK1 | |
| SCHEMBL17778258 | 0.79 | KMT2A (0.38) | KMT2AKDM4ERAB9AMEN1CHEK1 | |
| SCHEMBL16754508 | 0.79 | KMT2A (0.38) | KMT2AKDM4ERAB9AMEN1CHEK1 | |
| SCHEMBL19365662 | 0.79 | HTR1F (0.36) | KDM4EFAAHMAPTGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |