Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 5/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | KARS1 | Q15046 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365270 | 0.91 | WNT3A (0.40) | WNT3AKARS1GSK3BDYRK1AMTOR | |
| SCHEMBL19365751 | 0.85 | GSK3B (0.38) | GSK3BDYRK1AMAPTMTORFAAH | |
| SCHEMBL19670360 | 0.85 | KARS1 (0.40) | KARS1GSK3BDYRK1AMAPT | |
| SCHEMBL19365299 | 0.84 | FGFR4 (0.40) | WNT3AGSK3BMTORFAAH | |
| SCHEMBL19365743 | 0.84 | THRB (0.40) | KARS1GSK3BDYRK1AMTORTNIK | |
| SCHEMBL19365269 | 0.84 | KARS1 (0.45) | KARS1GSK3BDYRK1AIRAK4FAAH | |
| SCHEMBL19364853 | 0.83 | KARS1 (0.41) | HIF1AKARS1GSK3BDYRK1AFAAH | |
| SCHEMBL19365526 | 0.83 | KARS1 (0.41) | HIF1AKARS1GSK3BDYRK1AFAAH | |
| SCHEMBL17618560 | 0.82 | WNT3A (0.40) | WNT3AKARS1GSK3BMAPTMAP4K4 | |
| SCHEMBL19365313 | 0.81 | KMT2A (0.37) | HIF1AGSK3BDYRK1AMAPTFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |