Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 2/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365368 | 0.85 | TRPA1 (0.38) | MAPTMTORTRPA1TRPV3TRPV4 | |
| SCHEMBL19670214 | 0.84 | TRPA1 (0.38) | MAPTMTORTRPA1TRPV3TRPV4 | |
| SCHEMBL16238261 | 0.83 | KMT2A (0.39) | MAPTTRPA1TRPV3TRPV4KDM1A | |
| SCHEMBL19670221 | 0.80 | UBE2M (0.37) | MAPTMTORTRPA1TRPV3TRPV4 | |
| SCHEMBL17618399 | 0.79 | KMT2A (0.38) | MAPTKDM1AMAOAMAOBMEN1 | |
| SCHEMBL19705998 | 0.77 | TRPA1 (0.38) | MAPTTRPA1TRPV3TRPV4KDM1A | |
| SCHEMBL19670123 | 0.76 | TRPA1 (0.37) | MAPTTRPA1TRPV3TRPV4KDM1A | |
| SCHEMBL19670497 | 0.76 | MAPT (0.45) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL19670209 | 0.74 | CNR2 (0.36) | MAPTMTORTRPV3KDM1AMAOA | |
| SCHEMBL16775878 | 0.73 | KMO (0.38) | TRPA1TRPV3TRPV4KDM1AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |