Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19705998 | 0.91 | TRPA1 (0.38) | TRPA1TRPV3TRPV4CA2CA9 | |
| SCHEMBL19365749 | 0.88 | CA2 (0.42) | CHRM4CHRM5CHRM1CHRM3CA2 | |
| SCHEMBL19670249 | 0.86 | CA2 (0.42) | CHRM4CHRM5CHRM1CHRM3CA2 | |
| SCHEMBL19670214 | 0.84 | TRPA1 (0.38) | TRPA1TRPV3TRPV4CHRM4CHRM5 | |
| SCHEMBL16775878 | 0.83 | KMO (0.38) | TRPA1TRPV3TRPV4CA2CA9 | |
| SCHEMBL19364921 | 0.83 | KIF18A (0.38) | CHRM4CHRM5CHRM1CHRM3CA2 | |
| SCHEMBL17623988 | 0.82 | NPC1 (0.37) | CHRM4CHRM5CHRM1CHRM3CA2 | |
| SCHEMBL19365407 | 0.82 | MEN1 (0.49) | — | |
| SCHEMBL19706277 | 0.82 | CA2 (0.39) | TRPV3CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL19365573 | 0.82 | CA2 (0.39) | TRPV4CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |