Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 11/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 11/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365391 | 0.86 | DGAT2 (0.42) | DGAT2TLR8PIK3CDPIK3CAPIK3CG | |
| SCHEMBL19670322 | 0.82 | MAPK1 (0.38) | ITGB3ITGA2BKMOEPHB4NAMPT | |
| SCHEMBL19670398 | 0.81 | CTSK (0.38) | PIK3CDPIK3CAPIK3CGITGB3ITGA2B | |
| SCHEMBL19365753 | 0.81 | CA12 (0.41) | ITGB3ITGA2BKMO | |
| SCHEMBL19365617 | 0.80 | KMO (0.39) | PIK3CDPIK3CAPIK3CGKMOEGFR | |
| SCHEMBL19670450 | 0.78 | MEN1 (0.41) | PIK3CDPIK3CAPIK3CGEPHB4NAMPT | |
| SCHEMBL19706034 | 0.73 | ALDH1A1 (0.39) | PIK3CDPIK3CAPIK3CGKMO | |
| SCHEMBL19365656 | 0.71 | MAPK1 (0.42) | TLR8ITGB3ITGA2BNAMPT | |
| SCHEMBL16776336 | 0.71 | DGAT2 (0.44) | DGAT2TLR8ITGB3ITGA2BKMO | |
| SCHEMBL19670382 | 0.71 | NPY5R (0.42) | PIK3CDPIK3CAPIK3CGEPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |