Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365434 | 1.00 | VCP (0.41) | VCPTP53BP1GSK3BDYRK1AHTR1A | |
| SCHEMBL19365292 | 0.93 | VCP (0.40) | VCPTP53BP1GSK3BDYRK1AHTR1A | |
| SCHEMBL19364853 | 0.91 | KARS1 (0.41) | VCPGSK3BDYRK1APDE10APRKCA | |
| SCHEMBL19365526 | 0.91 | KARS1 (0.41) | VCPGSK3BDYRK1APDE10APRKCA | |
| SCHEMBL19670153 | 0.91 | VCP (0.41) | VCPTP53BP1GSK3BDYRK1AHTR1A | |
| SCHEMBL19365387 | 0.90 | VCP (0.35) | VCPPDE10APRKCAPRKCQ | |
| SCHEMBL19365287 | 0.90 | VCP (0.35) | VCPPDE10APRKCAPRKCQ | |
| SCHEMBL19670498 | 0.89 | KARS1 (0.41) | GSK3BDYRK1ATRPV1KARS1PTGS1 | |
| SCHEMBL19365756 | 0.87 | VCP (0.38) | VCPTP53BP1GSK3BDYRK1AHTR1A | |
| SCHEMBL19365394 | 0.86 | FAAH (0.39) | PDE10AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |