Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.37 |
| ▸ | CLK2 | P49760 | 7/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365526 | 0.93 | KARS1 (0.41) | KARS1FAAHVCPDHFRGSK3B | |
| SCHEMBL19364853 | 0.93 | KARS1 (0.41) | KARS1FAAHVCPDHFRGSK3B | |
| SCHEMBL19365292 | 0.92 | VCP (0.40) | KARS1PIM2CLK2LRRK2MAP3K12 | |
| SCHEMBL19365294 | 0.89 | VCP (0.35) | PIM2CLK2LRRK2MAP3K12SCN5A | |
| SCHEMBL19365269 | 0.88 | KARS1 (0.45) | KARS1FAAHABL1DHFRGSK3B | |
| SCHEMBL17618567 | 0.87 | KARS1 (0.41) | KARS1PIM2CLK2LRRK2MAP3K12 | |
| SCHEMBL19365440 | 0.86 | PIM2 (0.35) | PIM2CLK2LRRK2ABL1SCN5A | |
| SCHEMBL19365442 | 0.86 | FAAH (0.37) | PIM2CLK2LRRK2MAP3K12FAAH | |
| SCHEMBL19365436 | 0.86 | VCP (0.41) | KARS1FAAHVCPGSK3BDYRK1A | |
| SCHEMBL19365434 | 0.86 | VCP (0.41) | KARS1FAAHVCPGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |