Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 3/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 4/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19364853 | 1.00 | KARS1 (0.41) | KARS1PDE10AFAAHPRKCAPRKCQ | |
| SCHEMBL19365437 | 0.93 | KARS1 (0.41) | KARS1FAAHDHFRGSK3BDYRK1A | |
| SCHEMBL19365436 | 0.91 | VCP (0.41) | KARS1PDE10AFAAHPRKCAPRKCQ | |
| SCHEMBL19365434 | 0.91 | VCP (0.41) | KARS1PDE10AFAAHPRKCAPRKCQ | |
| SCHEMBL19365269 | 0.91 | KARS1 (0.45) | KARS1FAAHPRKCAPRKCQDHFR | |
| SCHEMBL19365387 | 0.88 | VCP (0.35) | PDE10APRKCAPRKCQVCPKDR | |
| SCHEMBL19365287 | 0.88 | VCP (0.35) | PDE10APRKCAPRKCQVCPKDR | |
| SCHEMBL19365380 | 0.88 | KARS1 (0.39) | KARS1FAAHDHFRGSK3BDYRK1A | |
| SCHEMBL19670159 | 0.87 | KARS1 (0.40) | KARS1PDE10AFAAHPRKCAPRKCQ | |
| SCHEMBL17618546 | 0.86 | KARS1 (0.41) | KARS1PDE10AFAAHPRKCAPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |