Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670316 | 1.00 | GRM4 (0.39) | GRM4CHRM4ARGSK3BDYRK1A | |
| SCHEMBL19365401 | 0.88 | MALT1 (0.40) | GSK3BDYRK1AMALT1FAAHJAK2 | |
| SCHEMBL19365400 | 0.88 | MALT1 (0.40) | GSK3BDYRK1AMALT1FAAHJAK2 | |
| SCHEMBL17618584 | 0.86 | CHRM4 (0.41) | GRM4CHRM4ARGSK3BDYRK1A | |
| SCHEMBL19670319 | 0.85 | FAAH (0.42) | GSK3BDYRK1AFAAHJAK2NTRK1 | |
| SCHEMBL19364826 | 0.85 | FAAH (0.42) | GSK3BDYRK1AFAAHJAK2NTRK1 | |
| SCHEMBL19365410 | 0.84 | RAB9A (0.41) | GSK3BDYRK1ACNR2ABL1 | |
| SCHEMBL19365409 | 0.84 | RAB9A (0.41) | GSK3BDYRK1ACNR2ABL1 | |
| SCHEMBL19365553 | 0.83 | CNR2 (0.42) | GSK3BDYRK1AFAAHCNR2 | |
| SCHEMBL19365560 | 0.83 | CNR2 (0.42) | GSK3BDYRK1AFAAHCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |