Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 4/20 | 0.33 |
| ▸ | KIT | P10721 | 4/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.33 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19364831 | 0.91 | CYP11B2 (0.41) | CYP11B2FGFR4WNT3AABL1GRM5 | |
| SCHEMBL19670435 | 0.90 | WNT3A (0.36) | CYP11B2FGFR4WNT3ACYP3A4ROCK1 | |
| SCHEMBL19365738 | 0.89 | FGFR4 (0.37) | CYP11B2FGFR4WNT3ACYP3A4ROCK1 | |
| SCHEMBL19365531 | 0.88 | FGFR4 (0.49) | FGFR4WNT3ACYP3A4ROCK1ABL1 | |
| SCHEMBL16776229 | 0.85 | CYP11B2 (0.37) | CYP11B2FGFR4WNT3ACYP3A4ROCK1 | |
| SCHEMBL19670515 | 0.85 | WNT3A (0.35) | WNT3AABL1 | |
| SCHEMBL19365327 | 0.84 | FAAH (0.36) | CYP11B2FGFR4WNT3AABL1GRM5 | |
| SCHEMBL19365719 | 0.81 | HTR2C (0.52) | CYP3A4MAPT | |
| SCHEMBL19365813 | 0.80 | RPS6KA3 (0.36) | CYP11B2WNT3AABL1CSF1RKIT | |
| SCHEMBL19364889 | 0.79 | FGFR4 (0.49) | CYP11B2FGFR4ABL1PORCN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |