Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 2/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | DLK1 | P80370 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365756 | 0.91 | VCP (0.38) | KARS1IDH1DYRK1AMAP3K12GSK3B | |
| SCHEMBL19670360 | 0.89 | KARS1 (0.40) | KARS1DYRK1AMAP3K12GSK3BDLK1 | |
| SCHEMBL19365431 | 0.89 | IDH1 (0.34) | IDH1TEKDYRK1AMAP3K12GSK3B | |
| SCHEMBL19365269 | 0.89 | KARS1 (0.45) | KARS1TEKUSP2CYP1A2CYP2C19 | |
| SCHEMBL19365526 | 0.88 | KARS1 (0.41) | KARS1HIF1ADYRK1AGSK3BFAAH | |
| SCHEMBL19364853 | 0.88 | KARS1 (0.41) | KARS1HIF1ADYRK1AGSK3BFAAH | |
| SCHEMBL19365545 | 0.86 | TEK (0.32) | IDH1TEKUSP2CYP2C19CYP3A4 | |
| SCHEMBL17618521 | 0.86 | KARS1 (0.39) | KARS1TEKUSP2CYP1A2CYP2C19 | |
| SCHEMBL19365437 | 0.85 | KARS1 (0.41) | KARS1DYRK1AMAP3K12GSK3BFAAH | |
| SCHEMBL19365743 | 0.82 | THRB (0.40) | KARS1TEKCYP1A2CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |