Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706290 | 0.93 | MAPT (0.39) | SCN10ATRPV3MAPTPTGS2KDM1A | |
| SCHEMBL19365548 | 0.91 | TRPV3 (0.37) | SCN10ATRPV3ARCRHR1PTGS2 | |
| SCHEMBL19365666 | 0.89 | HTR2C (0.41) | MAPTTRPV1 | |
| SCHEMBL19670327 | 0.85 | PIK3CD (0.36) | TRPV3CRHR1PTGS2KDM1ACHRNA7 | |
| SCHEMBL19670562 | 0.84 | ALOX15 (0.39) | TRPV3MAPTPTGS2KDM1ACHRNA7 | |
| SCHEMBL19706246 | 0.83 | BRAF (0.37) | SCN10AMAPTKDM1APRMT5WDR77 | |
| SCHEMBL19670548 | 0.83 | TRPM8 (0.38) | PHGDHTRPV3PTGS2KDM1ACHRNA7 | |
| SCHEMBL19365860 | 0.83 | CHRNA7 (0.36) | TRPV3ARKDM1ACHRNA7ABL1 | |
| SCHEMBL19365758 | 0.83 | FGFR4 (0.36) | SCN10ATRPV3PTGS2CHRNA7ABL1 | |
| SCHEMBL19365783 | 0.82 | RHOA (0.45) | KDM1ATRPV1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |