Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 7/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365787 | 0.91 | SCN10A (0.40) | TRPV3CRHR1CHRNA7SCN10AABL1 | |
| SCHEMBL19365666 | 0.89 | HTR2C (0.41) | HTR2CHTR2BHTR2A | |
| SCHEMBL19706290 | 0.87 | MAPT (0.39) | TRPV3SCN10AKDM1APTGS2 | |
| SCHEMBL19670562 | 0.84 | ALOX15 (0.39) | TRPV3CHRNA7ABL1CLK2KDM1A | |
| SCHEMBL19706271 | 0.84 | CNR2 (0.36) | TRPV3ABL1CLK2KDM1A | |
| SCHEMBL19365860 | 0.84 | CHRNA7 (0.36) | TRPV3CHRNA7ABL1ARKDM1A | |
| SCHEMBL19670548 | 0.84 | TRPM8 (0.38) | TRPV3CHRNA7ABL1KDM1APTGS2 | |
| SCHEMBL19365783 | 0.83 | RHOA (0.45) | KDM1A | |
| SCHEMBL19365405 | 0.83 | GABRA1 (0.39) | TRPV3CHRNA7KDM1AHTR2CHTR2B | |
| SCHEMBL19670327 | 0.82 | PIK3CD (0.36) | TRPV3CRHR1CHRNA7ABL1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |