Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706287 | 0.93 | HTR2A (0.43) | HTR2CHTR2ATRPM8CSF1RFAAH | |
| SCHEMBL19706290 | 0.89 | MAPT (0.39) | MEN1KMT2AMAPTTSHR | |
| SCHEMBL19365548 | 0.89 | TRPV3 (0.37) | HTR2CHTR2AHTR2B | |
| SCHEMBL19365787 | 0.89 | SCN10A (0.40) | TRPV1MAPT | |
| SCHEMBL19365405 | 0.87 | GABRA1 (0.39) | HTR2CHTR2AFAAHHTR2BCYP3A4 | |
| SCHEMBL19670562 | 0.87 | ALOX15 (0.39) | FAAHHSD17B10CYP3A4CYP2D6MAPT | |
| SCHEMBL19670548 | 0.86 | TRPM8 (0.38) | TRPM8TRPV1EGFRFGFR1KDR | |
| SCHEMBL19365783 | 0.85 | RHOA (0.45) | TRPV1 | |
| SCHEMBL19365860 | 0.85 | CHRNA7 (0.36) | FAAHEGFRFGFR1KDR | |
| SCHEMBL19706127 | 0.83 | TSHR (0.47) | HTR2CHTR2ACSF1RLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |