Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365864 | 0.88 | KMT2A (0.39) | TSHRKMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL19670574 | 0.87 | KDM4E (0.39) | TSHRKMT2ANPC1CA2CA9 | |
| SCHEMBL17624535 | 0.87 | KDM4E (0.39) | TSHRKMT2ANPC1CA2CA9 | |
| SCHEMBL19670497 | 0.84 | MAPT (0.45) | TSHRKMT2AKDRMAPTTRPV1 | |
| SCHEMBL19670572 | 0.83 | LMNA (0.35) | TSHRKMT2AHDAC3HDAC1HDAC2 | |
| SCHEMBL19365834 | 0.80 | CNR2 (0.51) | FAAH | |
| SCHEMBL19670537 | 0.80 | CNR2 (0.51) | FAAH | |
| SCHEMBL16785533 | 0.80 | CA2 (0.37) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL19670299 | 0.80 | FYN (0.43) | KMT2ACA2CA9MAPTTRPV1 | |
| SCHEMBL17624534 | 0.79 | KMT2A (0.40) | TSHRKMT2AHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |