Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.32 |
| ▸ | ABL1 | P00519 | 5/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.30 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.30 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706091 | 0.90 | ADORA2A (0.32) | HTR1FADORA2AABL1ADORA2BP2RX7 | |
| SCHEMBL16238775 | 0.85 | ADORA2A (0.33) | HTR1FADORA2AABL1ADORA2BGSK3B | |
| SCHEMBL16238778 | 0.85 | ADORA2A (0.33) | HTR1FADORA2AABL1ADORA2BGSK3B | |
| SCHEMBL19365507 | 0.79 | MAPT (0.37) | MCHR1 | |
| SCHEMBL16776202 | 0.75 | DGAT2 (0.34) | HTR1FADORA2AABL1ADORA2BGSK3B | |
| SCHEMBL19365678 | 0.72 | PDE10A (0.34) | DYRK1ACHRM4CACNA1GCACNA1HCACNA1I | |
| SCHEMBL19365433 | 0.72 | PDE10A (0.34) | DYRK1ACHRM4CACNA1GCACNA1HCACNA1I | |
| SCHEMBL19670514 | 0.71 | KARS1 (0.34) | ABL1DYRK1ACACNA1GCACNA1HCACNA1I | |
| SCHEMBL19670507 | 0.71 | KARS1 (0.34) | ABL1DYRK1ACACNA1GCACNA1HCACNA1I | |
| SCHEMBL19670383 | 0.69 | MEN1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |