Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 3/20 | 0.31 |
| ▸ | HTR2B | P41595 | 3/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.31 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.31 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365678 | 1.00 | PDE10A (0.34) | PDE10ANPC1RAB9APLK4MEN1 | |
| SCHEMBL19365440 | 0.93 | PIM2 (0.35) | NPC1RAB9AMEN1HSP90AA1KMT2A | |
| SCHEMBL19364877 | 0.92 | TRPV3 (0.38) | PLK4CNR1PRKCIDYRK1ATRPV3 | |
| SCHEMBL19365545 | 0.88 | TEK (0.32) | PLK4PRKCIDYRK1ATRPV3KDM4E | |
| SCHEMBL19365387 | 0.87 | VCP (0.35) | PDE10APRKCAPRKCQKDM4EALDH1A1 | |
| SCHEMBL19365287 | 0.87 | VCP (0.35) | PDE10APRKCAPRKCQKDM4EALDH1A1 | |
| SCHEMBL17618557 | 0.86 | CNR1 (0.33) | PDE10ANPC1RAB9APLK4MEN1 | |
| SCHEMBL17618559 | 0.86 | CNR1 (0.33) | PDE10ANPC1RAB9APLK4MEN1 | |
| SCHEMBL19364853 | 0.85 | KARS1 (0.41) | PDE10APRKCIDYRK1APRKCAPRKCQ | |
| SCHEMBL19365526 | 0.85 | KARS1 (0.41) | PDE10APRKCIDYRK1APRKCAPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |