SCHEMBL19366194

SCHEMBL19366194

CCOc1ccc(Cl)c(C(C)C)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 1/20 0.48
FFAR1 O14842 1/20 0.44
FFAR4 Q5NUL3 1/20 0.44
KMT2A Q03164 5/20 0.43
MEN1 O00255 4/20 0.43
PKM P14618 1/20 0.43
AKR1C3 P42330 1/20 0.41
AKR1C2 P52895 1/20 0.41
TSHR P16473 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
NPC1 O15118 1/20 0.41
APOBEC3G Q9HC16 1/20 0.41
L3MBTL1 Q9Y468 3/20 0.40
ALDH1A1 P00352 3/20 0.40
GAA P10253 2/20 0.40
KDM4E B2RXH2 2/20 0.40
TAS1R3 Q7RTX0 1/20 0.40
TAS1R1 Q7RTX1 1/20 0.40
TP53 P04637 1/20 0.40
CYP3A4 P08684 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21667969 0.87 KDM4E (0.44) FFAR1FFAR4KMT2AL3MBTL1ALDH1A1
SCHEMBL16962031 0.85 NQO1 (0.45) NQO1FFAR1FFAR4KMT2AMEN1
SCHEMBL21725535 0.85 NQO1 (0.48) NQO1FFAR1KMT2AMEN1PKM
SCHEMBL17125212 0.82 KDM4E (0.41) FFAR1FFAR4KMT2AMEN1TDP1
SCHEMBL26829098 0.82 CARM1 (0.41) FFAR1FFAR4KMT2AL3MBTL1ALDH1A1
SCHEMBL1494043 0.80 HTR2A (0.46) KMT2AMEN1THRBRORCHTT
SCHEMBL1548013 0.79 KDM4E (0.58) NQO1FFAR1FFAR4KMT2AMEN1
SCHEMBL16961251 0.79 NQO1 (0.42) NQO1FFAR1FFAR4KMT2AMEN1
SCHEMBL17125225 0.78 ALDH1A1 (0.43) FFAR4KMT2AALDH1A1GAAKDM4E
SCHEMBL16918737 0.78 THRB (0.38) KMT2ATP53THRBRORCHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3534709-B1 SUBSTITUTED SULFONYLAMIDE FOR COMBATING ANIMAL PESTS BAYER AG (DE) 2021-06-16 EP disclosed
US-10820591-B2 Substituted sulfonyl amides for controlling animal pests BAYER AKTIENGESELLSCHAFT (DE) 2020-11-03 US disclosed
US-20200288710-A1 SUBSTITUTED SULPHONAMIDES FOR CONTROLLING ANIMAL PESTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-09-17 US disclosed
EP-3429355-B1 SUBSTITUTED SULFONYLAMIDE FOR COMBATING ANIMAL PESTS BAYER CROPSCIENCE AG (DE) 2020-02-05 EP disclosed
US-20190269134-A1 SUBSTITUTED SULFONYL AMIDES FOR CONTROLLING ANIMAL PESTS BAYER AKTIENGESELLSCHAFT (DE) 2019-09-05 US disclosed
US-20170275301-A1 Benzenesulfonyl-Asymmetric Ureas and Medical Uses Thereof HELSINN HEALTHCARE SA (CH) 2017-09-28 US disclosed
WO-2017162390-A1 BENZENESULFONYL-ASYMMETRIC UREAS AND MEDICAL USES THEREOF HELSINN HEALTHCARE SA (CH) 2017-09-28 WO disclosed
WO-2017157735-A1 SUBSTITUTED SULFONYL AMIDES FOR CONTROLLING ANIMAL PESTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-09-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200288710-A1 SUBSTITUTED SULPHONAMIDES FOR CONTROLLING ANIMAL PESTS DDT, MPST, STOM NQO1 2523/4885FFAR1 4439/4885FFAR4 4549/4885
US-20190269134-A1 SUBSTITUTED SULFONYL AMIDES FOR CONTROLLING ANIMAL PESTS MLYCD, STOM, DDT NQO1 4089/4885FFAR1 1881/4885FFAR4 2515/4885
US-20170275301-A1 Benzenesulfonyl-Asymmetric Ureas and Medical Uses Thereof UTS2R, GHSR, GRPR NQO1 4386/4885FFAR1 119/4885FFAR4 208/4885
US-10820591-B2 Substituted sulfonyl amides for controlling animal pests MLYCD, STOM, DDT NQO1 4089/4885FFAR1 1881/4885FFAR4 2515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.