Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ADK | P55263 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ABL2 | P42684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19366442 | 0.83 | ADK (0.33) | ADKEGFR | |
| SCHEMBL19366587 | 0.81 | SRC (0.40) | ALDH1A1MAPTADKSRC | |
| SCHEMBL18902075 | 0.68 | BRD4 (0.34) | — | |
| SCHEMBL2111551 | 0.65 | ALDH1A1 (0.32) | ALDH1A1SRCABL1EGFR | |
| SCHEMBL30372731 | 0.64 | LMNA (0.48) | ALDH1A1KDRMAPTSRCABL1 | |
| SCHEMBL18902127 | 0.64 | JAK2 (0.35) | ALDH1A1KDM4EHPGDTSHR | |
| SCHEMBL30372295 | 0.62 | METTL3 (0.34) | KDRSRCABL1EGFRABL2 | |
| SCHEMBL21170650 | 0.60 | PDE4A (0.38) | ALDH1A1MAPTSRC | |
| SCHEMBL20899549 | 0.59 | HTT (0.40) | ALDH1A1KDRNPC1RAB9AKDM4E | |
| SCHEMBL18098819 | 0.59 | DYRK1A (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143018-A2 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. (US) | 2009-11-26 | — | — | WO | disclosed |