Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2785304 | 0.74 | SRC (0.49) | ADKCA12CA1CA2CA9 | |
| SCHEMBL19366587 | 0.74 | SRC (0.40) | ADKMEN1NR2F2KMT2ASRC | |
| SCHEMBL391944 | 0.72 | CA1 (0.47) | ADKCA12CA1CA2CA9 | |
| SCHEMBL20439496 | 0.69 | XDH (0.31) | — | |
| SCHEMBL19366522 | 0.69 | RIPK2 (0.31) | — | |
| SCHEMBL868823 | 0.68 | ADK (0.49) | ADKCA12CA1CA2CA9 | |
| SCHEMBL21251023 | 0.67 | KDM4E (0.32) | — | |
| SCHEMBL8256564 | 0.66 | GSK3B (0.39) | KMT2A | |
| SCHEMBL19937783 | 0.65 | ALDH1A1 (0.38) | — | |
| SCHEMBL1939924 | 0.64 | ADK (0.46) | ADKMEN1NR2F2KMT2ASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867236-B1 | NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-D]PYRIMIDINES AS LRRK2 INHIBITORS | PFIZER (US) | 2017-06-14 | — | — | EP | disclosed |