Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.42 |
| ▸ | GLP1R | P43220 | 8/20 | 0.41 |
| ▸ | PAOX | Q6QHF9 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.36 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16307723 | 0.96 | SLC6A5 (0.46) | SLC6A5GLP1RPAOXTSHRKDM4A | |
| SCHEMBL17029409 | 0.90 | CA2 (0.38) | GLP1RTSHRCA12CA1CA2 | |
| SCHEMBL12147645 | 0.90 | TSHR (0.47) | GLP1RTSHRCA12CA1CA2 | |
| SCHEMBL24393831 | 0.87 | CES2 (0.39) | PAOXTSHRCA12CA1CA2 | |
| SCHEMBL16426613 | 0.86 | MEN1 (0.40) | GLP1RTSHRCA12CA1CA2 | |
| SCHEMBL12655854 | 0.86 | MEN1 (0.40) | GLP1RTSHRCA12CA1CA2 | |
| SCHEMBL13035784 | 0.86 | MEN1 (0.40) | GLP1RTSHRCA12CA1CA2 | |
| SCHEMBL12850137 | 0.86 | MEN1 (0.40) | GLP1RTSHRCA12CA1CA2 | |
| SCHEMBL12673887 | 0.86 | GLP1R (0.48) | GLP1RTSHRCES2 | |
| SCHEMBL15107494 | 0.86 | CES2 (0.54) | GLP1RCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017189342-A1 | INSULIN DIMER-INCRETIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2017-11-02 | — | — | WO | disclosed |
| WO-2017160669-A1 | INSULIN-INCRETIN CONJUGATES | MERCK SHARP & DOHME CORP. (US) | 2017-09-21 | — | — | WO | disclosed |